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The Lab for Neurobiology of Psychiatric Disorders focuses on two main subjects.
We explore molecular and cellular mechanisms underlying various psychiatric disorders 
by using genetic mice models.  Our vision is that the impairments in the basis of these 
disorders are related not only to synaptic changes, but also to intrinsic ones, mainly 
excitability alterations, and our focus is on the axon initial segment. 
Our current focus is on autism, schizophrenia and depression. A more specific focus is 
on genetic mice models of autistic disorders such as Angelman syndrome and Rett 
syndrome. We aim to reveal the neurobiological basis of these psychiatric disorders by 
using interdisciplinary approach.
The lab also focuses on the basic processes underlying the effects of trans-cranial direct
current stimulation (tDCS). We investigate the molecular and cellular effects of small 
electrical fields on individual neurons and neuron ensembles. We employ DC fields in vitro 
and in vivo and examine the consequent activation of molecular pathways and excitability
and synaptic alterations in response to these manipulations. This exploration will decipher 
the processes and effects of ephaptic transmission in neurons.
The techniques employed by the lab are extracellular and intracellular electrophysiology
in slices, confocal and multiphoton imaging of fixed and live tissues, viral transfections, 
and basic molecular and biochemical methods.

 

Part of the lab will pursue clinical research in psychiatry. Our aim is to focus on clinical 
issues that face difficulties in the treatment of various psychiatric disorders. 
Our therapeutic approach is by employing novel pharmacotherapeutic strategies and tDCS, 
(each approach alone or a combination of the two). 
This type of studies will enhance our comprehension of the psychopathological mechanisms 
underlying the specific psychiatric disorders, and also enable to optimize novel therapeutic 
strategies in order to alleviate the symptoms in these psychiatric disorders.